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 James
N. MacLeod, VMD, PhD
Maxwell H. Gluck Equine Research Center
Department of Veterinary Science
University of Kentucky Lexington, Kentucky 40546-0099
Laboratory of Equine Musculoskeletal Sciences
Physical exertion and the musculoskeletal stress of athletic
events predispose both horses and humans to joint injuries.
In fact, pain and lameness associated with joint disease is
a primary variable that limits many athletic careers.
My laboratory conducts biomedical research on articular cartilage,
primarily focused on the cell biology of chondrocytes. We
study changes in chondrocyte gene expression that occur during
normal maturation, when joints develop arthritis, and associated
with efforts to heal joint surface lesions.
Additional experiments focus on how the function of cartilage
and synovial cells is regulated by cell/matrix interactions
and influenced by intra-articular medications.
Finally, we are interested in genomics and the identification
of genetic determinants that influence both congenital and
acquired musculoskeletal diseases.
Projects
- Articular Cartilage Maturation and Repair.
- Osteoarthritis Pathogenesis and Therapy.
- Cartilage-Restricted Fibronectin Isoform.
- Gene Mapping, SNP Genotyping, Association Studies, and
Transcriptional Profiling.
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